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Significant Shareholders

Shares in Issue: 530,412,678 1p Ordinary Shares

Last updated: 24th November 2020

Significant Shareholders

Amount

% Holding

Fidelity Management & Research

50,465,122

9.48

Slater Investment

41,741,894

7.84

BlackRock, Inc

36,196,710

6.80

John Dawson (beneficial and non-beneficial holdings)

29,976,402

5.60

F Van Lanschot Bankiers

29,514,372

5.54

MVM Life Science Partners LLP

23,967,019

4.50

Polar Capital Holdings

19,696,984

3.70

Investec Group

19,475,062

3.66

Rathbone Investment

17,880,512

3.36

Shareholdings of Directors & their families

Amount

% Holding

Peter Butterfield

412,461

0.08

David Cook

234,129

0.04

Nigel Clifford

180,663

0.04

Andrew Franklin

128,384

0.02

Richard Jones

15,000

0.00