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Significant Shareholders

Shares in Issue: 530,412,678 1p Ordinary Shares

Last updated: 24th November 2020

Significant Shareholders

Amount

% Holding

Fidelity Management & Research

53,317,753

9.98

Slater Investment

42,019,007

7.87

BlackRock, Inc

36,056,498

6.75

F Van Lanschot Bankiers

32,678,985

6.12

John Dawson (beneficial and non-beneficial holdings)

25,456,917

4.77

Polar Capital Holdings

22,207,692

4.16

Investec Group

20,687,183

3.87

Rathbone plc

18,428,800

3.45

Affiliated Managers Group

16,304,802

3.05

MVM Life Science Partners LLP14,870,613

2.78

Shareholdings of Directors & their families

Amount

% Holding

Peter Butterfield

412,461

0.08

David Cook

234,129

0.04

Nigel Clifford

180,663

0.04

Andrew Franklin

128,384

0.02

Richard Jones

15,000

0.00