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Significant Shareholders

Shares in Issue: 530,412,678 1p Ordinary Shares

Last updated: 24th September 2020

Significant Shareholders

Amount

% Holding

Fidelity Management & Research

49,810,760

9.39

Slater Investment

42,301,894

7.98

John Dawson (beneficial and non-beneficial holdings)

44,212,402

7.30

BlackRock Inc

27,451,889

5.18

Kempen Capital Management N.V.

26,621,969

5.01

MVM Life Science Partners LLP

24,760,663

4.70

Polar Capital Holdings

19,663,707

3.71

Investec Group18,187,402

3.43

GVQ Investment

18,006,489

3.39

Rathbone Investment17,423,951

3.29

Shareholdings of Directors & their families

Amount

% Holding

Peter Butterfield

412,461

0.08

David Cook

234,129

0.04

Nigel Clifford

180,663

0.04

Andrew Franklin

128,384

0.02

Richard Jones

15,000

0.00