Significant Shareholders

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Shares in Issue: 530,412,678 1p Ordinary Shares

Last updated: 24th November 2020

Significant Shareholders	Amount	% Holding
Fidelity Management & Research	53,317,753	9.97
Slater Investment	46,981,041	8.79
BlackRock, Inc	35,927,830	6.72
F Van Lanschot Bankiers	33,190,553	6.21
Polar Capital Holdings	22,844,255	4.27
Investec Group	20,893,668	3.91
John Dawson (beneficial and non-beneficial holdings)	18,876,402	3.50
Rathbone plc	18,486,216	3.46
Affiliated Managers Group	16,304,802	3.05

Shareholdings of Directors & their families	Amount	% Holding
Peter Butterfield	442,104	0.08
David Cook	234,129	0.04
Andrew Franklin	128,384	0.02
Richard Jones	15,000	0.00